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COMPONENTS
METABOLITES
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Name
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Abbreviation
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Fructose
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Fru
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Fructose 1-Phosphate
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F1P
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Fructose 6-Phosphate
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F6P
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Fructose 1,6-Bisphosphate
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F1,6BP
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Dihydroxyacetone Phosphate
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DHAP
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Glyceraldehyde
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GAH
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Glycerol
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GOH
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Glycerol 3-Phosphate
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GOP
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Glyceraldehyde 3-Phosphate
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GAP
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Adenosine Triphosphate
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ATP
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Adenosine Diphosphate
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ADP
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Adenosine Monophosphate
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AMP
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Nicotine Adenine Dinucleotide (Ox.)
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NAD
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Nicotine Adenine Dinucleotide (Ox.)
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NADH
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NOTE: Especial fluxes are denoted as follows:
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Input flux of Fru:
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Output flux of GAP:
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ENZYMES
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Name
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Abbreviation
|
E.C. Number
|
Mechanism
|
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Hexokinase
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HK
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2.7.1.1
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Irreversible random bi-bi¹
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Phosphofructokinase
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PFK
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2.7.1.11
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Hill
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F1,6BP Aldolase
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F1,6BP ALD
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4.1.2.13
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Reversible ordered uni-bi²
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F1P Aldolase
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F1P ALD
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4.1.2.13
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Reversible ordered uni-bi²
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Fructokinase
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FK
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2.7.1.4
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Reversible ordered bi-bi
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Alcohol Dehydrogenase
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ADH
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1.1.1.1
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Reversible ordered bi-bi²
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Glycerokinase
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GK
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2.7.1.30
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Reversible ordered bi-bi
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GOP Dehydrogenase
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GOPDH
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1.1.99.5
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Reversible ordered bi-bi
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Triokinase
|
TK
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2.7.1.28
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Irreversible ordered bi-bi
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Triose Phosphate Isomerase
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TPI
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5.3.1.1
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Equilibrium¹
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Adenylate Kinase
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AK
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2.7.4.3
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Equilibrium¹
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¹Voet, D. and Voet J.G., Biochemistry,
1990, John Wiley & Sons, Inc., New York
²Teusink, B., Pssarge, J., Reijenga, C.A.,
Esgalhado, van der Weijden, C.C., Schepper, M., Walsh, M.C., Bakker, B.M.,
van Dam, Karel, Westerhoff, H.V. and Snoep, J.L. "Can yeast glycolysis be
understood in terms of in vitro kinetics of the constituent
enzymes? Testing biochemistry" (2000) Eur. J. Biochem. 267,
5313-5329
NOTE: In the table above, when an accepted mechanism was known to the
author, a reference is given. Otherwise, the mechanism was chosen arbitrarily,
in order to enrich the dynamic behavior of the system.
Several rate equations are available
for PFK, so the type of the one used is indicated.
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