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|
PARAMETERS
All parameters, except
the equilibrium constants of
TPI and AK, were chosen arbitrarily. Units are also arbitrary.
Abbreviations are listed in
the page of components and
the meaning of the symbols is explained in the list
of rate equations.
|
HEXOKINASE
|
ALDOLASES
|
|
Symbol
|
HK
|
|
|
1.0
|
|
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1.5
|
|
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2.0
|
|
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0.8
|
|
|
Fru
|
|
|
ATP
|
|
|
Symbol
|
F1,6BP ALD
|
F1P ALD
|
|
|
5.0
|
10.0
|
|
|
0.7
|
0.1
|
|
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0.3
|
10.0
|
|
|
3.0
|
10.0
|
|
|
1.0
|
10.0
|
|
|
7.5
|
1.0
|
|
|
F1,6BP
|
F1P
|
|
|
DHAP
|
DHAP
|
|
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GAP
|
GAP
|
|
|
|
PHOSPHOFRUCTOKINASE
|
TRIOKINASE
|
|
Symbol
|
PFK
|
|
|
10.0
|
|
|
0.1
|
|
|
0.008
|
|
|
4.0
|
|
|
F6P
|
|
|
ATP
|
|
|
AMP
|
|
|
Symbol
|
TK
|
|
|
5.0
|
|
|
0.1
|
|
|
1.0
|
|
|
1.0
|
|
|
GAH
|
|
|
ATP
|
|
|
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ENZYMES SIMULATED WITH REVERSIBLE ORDERED BI-BI MECHANISM
|
|
Symbol
|
FK
|
ADH
|
GK
|
GOPDH
|
|
|
10.0
|
1.0
|
3.0
|
5.0
|
|
|
0.1
|
2.0
|
1.0
|
1.0
|
|
|
1.0
|
1.0
|
0.1
|
0.5
|
|
|
1.0
|
0.5
|
0.7
|
0.25
|
|
|
10.0
|
1.0
|
0.5
|
1.0
|
|
|
10.0
|
0.75
|
1.0
|
1.0
|
|
|
0.5
|
1.0
|
1.0
|
1.0
|
|
|
10.0
|
10.0
|
5.0
|
1.0
|
|
|
100.0
|
5.0
|
15.0
|
1.0
|
|
|
ATP
|
GAH
|
GOH
|
GOP
|
|
|
Fru
|
NADH
|
ATP
|
NAD
|
|
|
F1P
|
GOH
|
GOP
|
DHAP
|
|
|
ADP
|
NAD
|
ADP
|
NADH
|
|
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|
OTHER PARAMETERS
|
|
Symbol
|
Value
|
Meaning
|
|
|
0.045
|
Equilibrium constant of TPI¹
|
|
|
0.45
|
Equilibrium constant of AK¹
|
|
|
1.0
|
Ratio [ATP]/[ADP]
|
|
|
120.0
|
Total concentration of adenylates
|
|
|
1.0
|
Total concentration of nicotine adenine dinucleotide
|
|
|
2500.0
|
First-order output constant of GAP
|
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|
¹Teusink, B., Pssarge, J., Reijenga, C.A.,
Esgalhado, van der Weijden, C.C., Schepper, M., Walsh, M.C., Bakker, B.M.,
van Dam, Karel, Westerhoff, H.V. and Snoep, J.L. "Can yeast glycolysis be
understood in terms of in vitro kinetics of the constituent
enzymes? Testing biochemistry" (2000) Eur. J. Biochem. 267,
5313-5329
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