SYSTEM - FRUCTOSE CATABOLISM

A portion of fructose catabolism, consisting of 11 enzymes and 14 metabolites, was chosen as an example of a metabolic network. The reaction scheme is shown below. The system receives an input flux of fructose (Fru) and the response is defined as the output of glyceraldehyde 3-phosphate (GAP), which is assumed to be proportional to the concentration of this metabolite. Due to the breakage of the hexoses into trioses, the overall stoichiometry of the network is 1:2.

For a comprehensive list of abbreviations, see the list of components.

Figure: Fructose catabolism and adenilate kinase (AK) reaction

For simulating the response of the system, a dynamic model was built using deterministic ordinary differential equations. This network is a branched system. The branch involving fructose 1-phosphate (F1P) occurs in liver, whereas in muscle fructose is converted to fructose 6-phosphate (F6P) [Voet, D. and Voet J.G., Biochemistry, 1990, John Wiley & Sons, Inc., New York.]. However, transport processes between tissues were not included in the model, because they are immaterial to the purpose of illustrating the calculation of functional derivatives.

Copyright © 2003-2013 Antonio Sánchez Torralba
Last modified:
Monday, 04-Mar-2013 11:58:25 CET